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Strain - Detail

NBRP ID S90405
Strain Name myc2, Galpha2-, Ga2-, myc-2, Gα2-
Strain Summary Gα2 null mutant
Strain Descriptor gpaB-
Systematic Name DBS0236575
Species Dictyostelium discoideum
Category Recombinant
Parental Strain DH1
Mutagenesis Method homologous recombination
Mutagenesis Detail pMYC14B
Associated Gene gpaB 
Foreign Gene none
Genotype axeA1,axeB1,axeC1,gpaB-[pMYC14B],pyr5-6-[pRG24],ura+
Phenotype axenic, null mutant
Axenic Growth Y
Viable Spore Formation NO
References Chen MY, Devreotes PN, Gundersen RE.
Serine 113 is the site of receptor-mediated phosphorylation of the Dictyostelium G protein alpha-subunit G alpha 2.
J. Biol. Chem.  (1994)  269(33)   20925-30  
[PubMed ID = 8063709]  [RRC reference
Cha I, Lee SH, Jeon TJ.
Chemoattractant-mediated Rap1 activation requires GPCR/G proteins.
Mol. Cells  (2010)  30(6)   563-7  
[PubMed ID = 21103944]  [RRC reference
Lilly PJ, Devreotes PN.
Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes.
J. Cell Biol.  (1995)  129(6)   1659-65  
[PubMed ID = 7790361]  [RRC reference
Gundersen RE.
Phosphorylation of the G protein alpha-subunit, G alpha 2, of Dictyostelium discoideum requires a functional and activated G alpha 2.
J. Cell. Biochem.  (1997)  66(2)   268-76  
[PubMed ID = 9213227]  [RRC reference
Other Information
Depositor DSC
Source P. Devreotes
Use Condition A
DSC DBS0236575